Sensitivity of Hartmannella (Acanthamoeba) to 5-fluorocytosine, hydroxystilbamidine, and other substances
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منابع مشابه
Sensitivity of Hartmannella (Acanthamoeba) to 5-fluorocytosine, hydroxystilbamidine, and other substances.
The effect of 24 anti-amoebic and other chemotherapeutic compounds on six strains of hartmannellid amoebae was studied by tissue culture, agar diffusion, and liquid axenic culture. Of the recognized anti-amoebic compounds only one inhibited growth of the amoebae, which were remarkable for their resistance. Two compounds, hydroxystilbamidine isethionate and 5-fluorocytosine, showed some amoebici...
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Two patients with urinary candidiasis were treated with 5-fluorocytosine. Serum levels of the drug and a study of its excretion in urine are recorded together with a brief account of its activity in body fluids. Evidence of toxicity was not observed with dosages of from 2 to 5 g a day.
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Ocular penetration of 5-fluorocytosine (5FC) was studied in uninfected rabbits after subconjunctival and oral administration. With oral administration, 5FC achieved therapeutic levels in both the vitreous and aqueous humors. The use of a pharmacokinetic model permitted objective comparison of kinetic events within the eye chambers and the serum. The rates of entry and elimination in the vitreou...
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A cylinder plate bioassay for 5-fluorocytosine (5-FC) is described which permits determination of 5-FC concentrations in biological fluids in the presence of amphotericin B. Using this assay, we determined serum concentrations in 12 patients after a single dose of drug and in 8 patients receiving daily 5-FC at 6-hr intervals (4 to 120 days). Drug was detectable in serum as early as 0.5 hr and c...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1970
ISSN: 0021-9746
DOI: 10.1136/jcp.23.8.649